{"id":16441,"date":"2026-04-14T15:39:54","date_gmt":"2026-04-14T13:39:54","guid":{"rendered":"https:\/\/servireach.com\/blog\/characterisation-testing-under-reach-how-to-properly-demonstrate-substance-identity\/"},"modified":"2026-04-14T15:44:48","modified_gmt":"2026-04-14T13:44:48","slug":"characterisation-testing-under-reach-how-to-properly-demonstrate-substance-identity","status":"publish","type":"post","link":"https:\/\/servireach.com\/en\/blog\/characterisation-testing-under-reach-how-to-properly-demonstrate-substance-identity\/","title":{"rendered":"Characterisation testing under REACH: how to properly demonstrate substance identity"},"content":{"rendered":"\n<p>Registering a substance under the REACH Regulation is not just a documentary exercise: it is a technical process in which <strong>correct substance identification<\/strong> is critical. Incomplete or poorly justified characterisation may lead to <strong>ECHA comments, delays in the registration process, or even the invalidation of the dossier<\/strong>. <\/p>\n\n<p>In this context, analytical testing is not a mere formality, but the foundation on which the entire regulatory strategy is built.<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>What does REACH require to demonstrate substance identity?<\/strong><\/h2>\n\n<p>REACH requires robust demonstration of:<\/p>\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-group has-background is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-fc9f69e7 wp-block-group-is-layout-flex\" style=\"background-color:#b1c9bd59;line-height:2\">\n<figure class=\"wp-block-image size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"300\" src=\"https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-200x300.jpg\" alt=\"\" class=\"wp-image-16336\" srcset=\"https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-200x300.jpg 200w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-683x1024.jpg 683w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-100x150.jpg 100w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-768x1152.jpg 768w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-1024x1536.jpg 1024w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-1365x2048.jpg 1365w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-600x900.jpg 600w, https:\/\/servireach.com\/wp-content\/uploads\/2026\/04\/female-scientist-with-safety-glasses-holding-test-tube-lab-scaled.jpg 1707w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure>\n\n\n\n<p style=\"line-height:2.5\">\u2022 <strong>Chemical structure<\/strong> <br\/>\u2022 <strong>Composition<\/strong><br\/>\u2022 Degree of <strong>purity<\/strong><br\/>\u2022 Profile of <strong>relevant impurities<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div>\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p><strong>All of this must be based on analytical data obtained from the substance as manufactured or imported, ensuring that the information accurately reflects the material placed on the market.<\/strong><\/p>\n\n<h2 class=\"wp-block-heading\"><strong>Spectroscopic techniques: confirming molecular structure<\/strong><\/h2>\n\n<p>The first step in characterisation is to validate chemical identity through spectroscopic techniques. These provide a unique \u201cfingerprint\u201d of the substance. <\/p>\n\n<p>The most commonly used include:<\/p>\n\n<ul class=\"wp-block-list\">\n<li style=\"line-height:2\">UV\/Vis<\/li>\n\n\n\n<li style=\"line-height:2\">IR (infrared)<\/li>\n\n\n\n<li style=\"line-height:2\">NMR (nuclear magnetic resonance)<\/li>\n\n\n\n<li style=\"line-height:2\">Mass spectrometry (MS)<\/li>\n<\/ul>\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p>Combined, these techniques provide strong evidence of <strong>molecular structure<\/strong>, a key element within the REACH dossier.<\/p>\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<h2 class=\"wp-block-heading\"><strong>Chromatographic techniques: understanding real composition<\/strong><\/h2>\n<\/div>\n\n<p>Beyond identity, REACH requires a clear understanding of what the substance actually contains.<\/p>\n\n<p>Chromatographic techniques such as GC or HPLC allow:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Quantification of the <strong>main constituent <\/strong><\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li>Identification and measurement of <strong>impurities <\/strong><\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li>Evaluation of <strong>composition variability <\/strong><\/li>\n<\/ul>\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p>This aspect is particularly critical, as poor definition of composition may compromise correct substance identification or its toxicological profile.<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>Complex cases: when additional techniques are required<\/strong><\/h2>\n\n<p>For inorganic substances, UVCBs or complex compositions, standard characterisation is often not sufficient.<\/p>\n\n<p>In these cases, it is common to rely on techniques such as:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>X-ray diffraction or fluorescence (XRD, XRF)<\/li>\n\n\n\n<li>Elemental spectroscopy (AAS, ICP-OES, ICP-MS)<\/li>\n<\/ul>\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>The key is not to apply more techniques, but to <strong>select the appropriate ones depending on the nature of the substance<\/strong> and the regulatory approach.<\/p>\n<\/div>\n<\/div>\n\n<p><\/p>\n\n<h2 class=\"wp-block-heading\"><strong>Beyond testing: interpretation and dossier consistency<\/strong><\/h2>\n\n<p>One of the most common mistakes does not occur in the laboratory, but <strong>in the interpretation of results<\/strong>.<\/p>\n\n<p>Analytical data must:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Be consistent with each other<\/li>\n\n\n\n<li>Clearly justify the substance identity<\/li>\n\n\n\n<li>Be aligned with the registration strategy (mono-constituent, multi-constituent, UVCB, etc.)<\/li>\n<\/ul>\n\n<div style=\"height:37px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p><strong>This is where regulatory expertise makes the difference between an accepted dossier and one that is challenged.<\/strong><\/p>\n\n<p>Analytical characterisation is not an isolated requirement under REACH: it is <strong>the pillar supporting the entire registration<\/strong>. Addressing it strategically helps reduce risks, optimise costs and accelerate the process. <\/p>\n\n<p>At <a href=\"https:\/\/servireach.com\/en\/contact\/\">ServiREACH<\/a>, we support companies in going beyond analytical data by integrating:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Coordination with specialised laboratories<\/li>\n\n\n\n<li>Expert review of results<\/li>\n\n\n\n<li>Technical preparation of the dossier in line with REACH<\/li>\n<\/ul>\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h4 class=\"wp-block-heading\"><strong>Because under REACH, analysing is not enough:<\/strong> <strong>results must be properly interpreted and justified.<\/strong><\/h4>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Registering a substance under the REACH Regulation is not just a documentary exercise: it is a technical process in which correct substance identification is critical. Incomplete or poorly justified characterisation may lead to ECHA comments, delays in the registration process, or even the invalidation of the dossier. In this context, analytical testing is not a [&hellip;]<\/p>\n","protected":false},"author":85,"featured_media":16443,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[763],"tags":[],"class_list":["post-16441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Characterisation testing under REACH: how to properly demonstrate substance identity - Servireach<\/title>\n<meta name=\"description\" content=\"Characterisation testing under REACH: how to properly demonstrate substance identity\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/servireach.com\/en\/blog\/characterisation-testing-under-reach-how-to-properly-demonstrate-substance-identity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Characterisation testing under REACH: how to properly demonstrate substance identity - 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